Manglik lab @ UCSF

Aashish Manglik

Associate Professor, Departments of Pharmaceutical Chemistry and Anesthesia

Research in the lab is focused on decoding the molecular basis of transmembrane signaling and transport. The particular systems we study lie at the intersection of human health and protein science. We utilize a broad range of methods in structural biology, protein biophysics, pharmacology, and protein engineering to understand how cells recognize and respond to their extracellular environment and maintain intracellular homeostasis.

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

less than 1 minute read

We recently published “Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells” in eLife.

Molecular Basis of Opioid Action: From Structures to New Leads

1 minute read

We recently published “Molecular Basis of Opioid Action: From Structures to New Leads” in Biological Psychiatry.

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

less than 1 minute read

We recently published “Smoothened stimulation by membrane sterols drives Hedgehog pathway activity” in Nature.

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

less than 1 minute read

We recently published “Development of an antibody fragment that stabilizes GPCR/G-protein complexes” in Nature Communications.

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

less than 1 minute read

We recently published “Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor” in eLife.

Aashish Manglik

Recent Posts

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

Molecular Basis of Opioid Action: From Structures to New Leads

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor