Posts by Tag

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter

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We recently published “Structure-based discovery of conformationally selective inhibitors of the serotonin transporter” in Cell.

Structural basis of odorant recognition by a human odorant receptor

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We recently published “Structural basis of odorant recognition by a human odorant receptor” in Nature.

Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling

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We recently published “Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling” in eLife.

Autoantibody mimicry of hormone action at the thyrotropin receptor

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We recently published “Autoantibody mimicry of hormone action at the thyrotropin receptor” in Nature.

Selective G protein signaling driven by substance P–neurokinin receptor dynamics

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We recently published “Selective G protein signaling driven by substance P–neurokinin receptor dynamics” in Nature Chemical Biology.

Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody

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We recently published “Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody” in Hedgehog Signaling.

Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia

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We recently published “Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia” in Cell.

Surface Proteomics Reveals CD72 as a Target for In Vitro–Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL

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We recently published “Surface Proteomics Reveals CD72 as a Target for In Vitro–Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL” in Cancer ...

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

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We recently published “CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes” in bioRxiv.

Protein design and variant prediction using autoregressive generative models

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We recently published “Protein design and variant prediction using autoregressive generative models” in Nature Communications.

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

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We recently published “Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits” in PLOS Biology.

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

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We recently published “An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike” in Science.

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit

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We recently published “Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit” in Proceedings of the Nat...

Universal Polymerase Chain Reaction and Antibody Testing Demonstrate Little to No Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in a Rural Community

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We recently published “Universal Polymerase Chain Reaction and Antibody Testing Demonstrate Little to No Transmission of Severe Acute Respiratory Syndrome Co...

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

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We recently published “Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2” in Nature Chemical Biology.

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

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We recently published “Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms” in Science.

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

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We recently published “Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms” in Nature.

β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19

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We recently published “β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19” in Circulation.

Test performance evaluation of SARS-CoV-2 serological assays

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We recently published “Test performance evaluation of SARS-CoV-2 serological assays” in medRxiv.

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

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We recently published “Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells” in eLife.

Molecular Basis of Opioid Action: From Structures to New Leads

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We recently published “Molecular Basis of Opioid Action: From Structures to New Leads” in Biological Psychiatry.

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

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We recently published “Smoothened stimulation by membrane sterols drives Hedgehog pathway activity” in Nature.

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

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We recently published “Development of an antibody fragment that stabilizes GPCR/G-protein complexes” in Nature Communications.

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

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We recently published “Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor” in eLife.

Structure of the µ-opioid receptor–G_i protein complex

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We recently published “Structure of the µ-opioid receptor–Gi protein complex” in Nature.

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

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We recently published “A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action” in Neuron.

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

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We recently published “Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling” in Proceedings of the National A...

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

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We recently published “Yeast surface display platform for rapid discovery of conformationally selective nanobodies” in Nature Structural & Molecular Biol...

Structural Basis for G Protein-Coupled Receptor Activation

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We recently published “Structural Basis for G Protein-Coupled Receptor Activation” in Biochemistry.

Nanobodies to Study G Protein–Coupled Receptor Structure and Function

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We recently published “Nanobodies to Study G Protein–Coupled Receptor Structure and Function” in Annual Review of Pharmacology and Toxicology.

Structure-based discovery of opioid analgesics with reduced side effects

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We recently published “Structure-based discovery of opioid analgesics with reduced side effects” in Nature.

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

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We recently published “Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation” in Nature.

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

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We recently published “Allosteric coupling from G protein to the agonist-binding pocket in GPCRs” in Nature.

Crystal structure of the human σ₁ receptor

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We recently published “Crystal structure of the human σ1 receptor” in Nature.

High-density grids for efficient data collection from multiple crystals

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We recently published “High-density grids for efficient data collection from multiple crystals” in Acta Crystallographica Section D Structural Biology.

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

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We recently published “Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging” in Proceedings of the National Academy of ...

Structural insights into µ-opioid receptor activation

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We recently published “Structural insights into µ-opioid receptor activation” in Nature.

Propagation of conformational changes during μ-opioid receptor activation

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We recently published “Propagation of conformational changes during μ-opioid receptor activation” in Nature.

Structural basis for nucleotide exchange in heterotrimeric G proteins

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We recently published “Structural basis for nucleotide exchange in heterotrimeric G proteins” in Science.

Structural Insights into the Dynamic Process of β₂-Adrenergic Receptor Signaling

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We recently published “Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling” in Cell.

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

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We recently published “G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)” in Journa...

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