Research in the lab is focused on decoding the molecular basis of transmembrane signaling and transport.
The particular systems we study lie at the intersection of human health and protein science.
We utilize a broad range of methods in structural biology, protein biophysics, pharmacology, and protein engineering to understand how cells recognize and respond to their extracellular environment and maintain intracellular homeostasis.
Latest papers
Distinct activation mechanisms underlie ligand efficacy at a GPCR
Howard MK, Fine EJ, Srinivasan K, …, Manglik A, Coyote-Maestas W
Programming Targeted Immune Cell Migration Using Orthogonal Chemokine-Receptor Pairs
Lee J, Srinivasan K, Llinas del Torrent C, …, Manglik A, Lim WA
Development of a random background to understand ligand optimization
Xu X, Mailhot O, Correy GJ, …, Srinivasan K, …, Manglik A, …, Shoichet BK
Efficient experimental characterization of the GPCRome via deep receptor scanning
Tedman A, Goel M, Shah S, Howard MK, …, Manglik A, …, Schlebach JP
Allosteric Gating Mechanism Regulates Odorant Selectivity and Antagonism in Odorant Receptors
Ma N, Marie M, Takase D, Del Torrent Masachs CL, Aguilar J, Manglik A, Matsunami H, Vaidehi N
All publications
