Manglik lab @ UCSF

Aashish Manglik

Associate Professor, Departments of Pharmaceutical Chemistry and Anesthesia

Research in the lab is focused on decoding the molecular basis of transmembrane signaling and transport. The particular systems we study lie at the intersection of human health and protein science. We utilize a broad range of methods in structural biology, protein biophysics, pharmacology, and protein engineering to understand how cells recognize and respond to their extracellular environment and maintain intracellular homeostasis.

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

less than 1 minute read

We recently published “Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2” in Nature Chemical Biology.

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

less than 1 minute read

We recently published “Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms” in Science.

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

1 minute read

We recently published “Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms” in Nature.

β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19

1 minute read

We recently published “β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19” in Circulation.

Test performance evaluation of SARS-CoV-2 serological assays

less than 1 minute read

We recently published “Test performance evaluation of SARS-CoV-2 serological assays” in medRxiv.

Aashish Manglik

Recent Posts

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19

Test performance evaluation of SARS-CoV-2 serological assays