Manglik lab @ UCSF

Aashish Manglik

Associate Professor, Departments of Pharmaceutical Chemistry and Anesthesia

Research in the lab is focused on decoding the molecular basis of transmembrane signaling and transport. The particular systems we study lie at the intersection of human health and protein science. We utilize a broad range of methods in structural biology, protein biophysics, pharmacology, and protein engineering to understand how cells recognize and respond to their extracellular environment and maintain intracellular homeostasis.

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

less than 1 minute read

We recently published “CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes” in bioRxiv.

Protein design and variant prediction using autoregressive generative models

less than 1 minute read

We recently published “Protein design and variant prediction using autoregressive generative models” in Nature Communications.

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

less than 1 minute read

We recently published “Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits” in PLOS Biology.

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

less than 1 minute read

We recently published “An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike” in Science.

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit

less than 1 minute read

We recently published “Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit” in Proceedings of the Nat...

Aashish Manglik

Recent Posts

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

Protein design and variant prediction using autoregressive generative models

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit