Members
Aashish Manglik
Associate Professor, Departments of Pharmaceutical Chemistry and Anesthesia
Email: aashish.manglik@ucsf.edu
Twitter: @AashishManglik
Aashish was an undergraduate at Washington University in St. Louis, where he worked in the lab of Jeff McKinney on Salmonella-host interactions. He moved to California in 2008 to join the Stanford Medical Scientist Training Program. There, he worked with Brian Kobilka as a graduate student to elucidate different aspects of GPCR function, resulting in a number of important contributions to our current understanding of opioid and adrenergic receptors. After finishing his medical training in May 2016, Aashish began his independent research career as the first Stanford Distinguished Fellow at Stanford University School of Medicine within the Department of Molecular and Cellular Physiology. He subsequently began as an assistant professor at UCSF in fall of 2017.
Jakki Stevens
Lab Manager Extraordinaire
Email: jacqueline.stevens@ucsf.edu
Jakki is the lab manager for both the Manglik and Shoichet Labs with expertise in protein biochemistry. She received my BS in Chemistry at the University of Kansas where she honed her skills in the outer-membrane focused lab of Joanna Slusky before venturing to the GPCR world. With a passion for scientific research and a meticulous attention to detail, Jakki play a pivotal role in ensuring the smooth operation of our cutting-edge research. Jakki facilitates the day-to-day activities, coordinate equipment, and assist lab members in achieving their scientific goals.
Christian Billesbølle
Assistant Proffesional Researcher
Email: christianbache.billesboelle@ucsf.edu
Christian hails from Denmark, where he received a bachelor’s degree in Pharmacy and a master’s degree in Human Biology at the University of Copenhagen. He conducted his graduate studies in the lab of Ulrik Gether, where he studied the mechanism of the prototypical transmembrane transporter LeuT by new spectroscopic methods. Christian spent a year in the laboratory of Jonathan Javitch as a visiting Bikuben research scholar. After a short postdoc in the lab of Hans Bräuner-Osborne’s lab, Christian decided to come to the states. In the Manglik lab, he is examining the structural and biophysical basis of iron transport with support from the Alfred Benzon Foundation.
Simone Harrison
Graduate student, Biophysics
Email: simone.harrison@ucsf.edu
Simone received her bachelor’s degree in Molecular Biology and Biochemistry from Wesleyan University in 2018. At Wesleyan, she worked in the Olson lab to study the biophysical properties of novel pathogenic proteins from the genus Vibrio. After college, Simone worked for 2 years at Vanderbilt University in the Chazin lab as a Research Assistant, studying the structural basis of nutrient sequestration and inflammation mediated by S100 proteins, and aiding with protein production. In the Manglik lab, she is studying the molecular details of the interaction between GPCRs and GRKs, as well as the mechanism of GPCR mediated regulation of the hedgehog signaling pathway.
Daniel Hogan
Bioinformatics programmer
Email: daniel.hogan@ucsf.edu
Daniel graduated from Stanford, where he worked on single-molecule biophysics with Dr. Steven Block. In the Manglik lab, Daniel works to improve and expand the lab’s computational resources. He’s passionate about open science, open data, and open-source software. Outside of lab, Daniel can usually be found running or playing board games.
Matthew Howard
Graduate student,Tetrad (joint with Coyote-Maestas Lab)
Email: matthew.howard@ucsf.edu
Twitter: @matthewkhoward
Matt comes to the Manglik Lab by way of Washington University in St. Louis where he studied chemistry and biology. At WashU, he worked in the Jackrel Lab to engineer protein disagreggases and investigate microbial amyloid proteins. In the Manglik Lab, Matt develops high-throughput screening assays to enable deep mutational scanning of many GPCR phenotypes. These approaches are applied across diverse receptor systems to study the fundamental principles of ligand recognition and signal transduction
Karthik Srinivasan
Postdoctoral Scholar
Email: karthik.srinivasan@ucsf.edu
Karthik earned his Bachelor of Engineering in Mechanical Engineering and his Master of Science in Biological Sciences from BITS Pilani Goa Campus in India. During his Master’s thesis, he conducted research as a visiting student in the lab of Andre Hoelz at Caltech, focusing on elucidating the structure of a multiprotein component of the nuclear pore complex. Pursuing his doctoral studies, Karthik transitioned to the lab of Nicholas Noinaj at Purdue University, where he devised an innovative approach to isolate the chloroplast import machinery from plant biomass. Deepening his engagement with membrane protein structural biology, Karthik then joined the Manglik lab where he presently investigates the thyroid stimulating hormone receptor and its implications in autoimmune thyroid diseases.
Yue Wan
Postdoctoral Scholar
Email: yue.wan@ucsf.edu
Yue is from Northeast of China and earned her PhD degree from SIAIS at ShanghaiTech University in 2021. During her doctral studies, she conducted research in Guang Yang’s lab at SIAIS and Richard Lerner’s lab at Scripps, focusing on the development of membrane protein antibody screening platforms and the discovery of therapeutic antibodies targeting chemokine receptor. Following her PhD, she gained industry experience for eight months before joining Manglik’s lab. Currently, her interests lie in generating high-quality nanobody libraries and exploring high-throughput screening methods targeting GPCRs.
Huixia Wang
Postdoctoral Scholar
Email: Huixia.Wang@ucsf.edu
Huixia comes to the lab from … continue bio
Hiroyuki Okamoto
Postdoctoral Scholar
Email: Hiroyuki.Okamoto@ucsf.edu
Twitter: @hhokamoto_en
Hiro came from Japan, where he earned his Ph.D. in Biological Science at the University of Tokyo. He conducted his graduate studies in the lab of Osamu Nureki, where he elucidated the structural basis of melatonin receptors using cryogenic electron microscopy (cryo-EM). After he received his Ph.D., Hiro decided to join the Manglik lab, where he is trying to find ligands of some classA GPCRs using biochemical and biophysical approaches with support from the Human Frontier Science Program (HFSP) Long Term Fellowship (LTF) and the Japan Society for the Promotion of Science (JSPS).
Yile Dai
Postdoctoral Scholar
Email: Yile.Dai@ucsf.edu
Yile earned his Ph.D. from Yale University.
Former members
Chase Webb
Graduate student, PSPG (joint with Shoichet Lab)
Nick Hoppe
Graduate student, Biophysics
Bryan Faust
Graduate student, Biophysics (joint with Cheng Lab)
Benjamin Barsi-Rhyne
Graduate student, Tetrad (joint with von Zastrow Lab)
Julian Harris
Graduate student, CCB
Melanie O’Rourke
Lab manager
Ishan Deshpande
Postdoctoral fellow
Dora Obgonna
Summer student, SRTP (2021)
Next: Undergraduate student, UCSD
Ashley Olivares Rojas
Summer student, BAYS (2021)
Next: High school student, KIPP
Jiahao Liang
Research associate and lab manager (2017–2020)
Next: Graduate student at Stanford University
Zhen Tong
Undergraduate student from Nankai University (2019)
Next: Graduate student at the University of Chicago
Anastasiia Sukalskaia
Master’s student from the University of Copenhagen (2018–2019)
Next: Graduate student at the University of Zurich
Simon Schneider
Master’s student from Goethe University (2019)
Next: Master’s student at Goethe University
Preetham Bachina
Undergraduate summer student from Rice University (2018)
Next: Undergraduate at Rice University
Yagmur Muftuoglu
Postdoctoral scholar (2016–2017)
Next: Medical student at Stanford University
Joining
We are actively recruiting highly motivated graduate students and postdoctoral fellows interested in problems at the intersection of transmembrane signaling, protein biophysics, and human disease.
Interested graduate students should apply to one of the UCSF graduate programs.
Postdoctoral fellows should contact Aashish directly with a CV, research proposal, and three references.